S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Ntg1p
Description	DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; required for maintaining mitochondrial genome integrity; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
GO Terms: Biological Process	level 2: metabolic process level 5: cellular response to oxidative stress level 5: cellular response to DNA damage stimulus level 6: DNA repair level 6: base-excision repair, AP site formation level 7: base-excision repair level 8: nucleotide-excision repair, DNA incision, 5'-to lesion level 9: positive regulation of mitochondrial DNA replication
GO Terms: Molecular Function	level 2: catalytic activity level 3: hydrolase activity level 3: lyase activity level 4: hydrolase activity, acting on glycosyl bonds level 5: DNA-(apurinic or apyrimidinic site) endonuclease activity level 5: DNA N-glycosylase activity level 5: class I DNA-(apurinic or apyrimidinic site) endonuclease activity level 5: DNA binding level 7: oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity level 7: oxidized purine nucleobase lesion DNA N-glycosylase activity
GO Terms: Cellular Component	level 4: mitochondrion level 5: nucleus
External source	Open in SGD