S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Ncl1p
Description	S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase; methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120
GO Terms: Biological Process	level 3: methylation level 4: regulation of metabolic process level 5: RNA methylation level 6: tRNA methylation level 6: cellular response to hydrogen peroxide level 7: regulation of translation level 8: tRNA wobble base cytosine methylation level 8: tRNA processing
GO Terms: Molecular Function	level 3: transferase activity level 5: methyltransferase activity level 5: RNA binding level 6: tRNA binding level 8: tRNA (cytosine-5-)-methyltransferase activity
GO Terms: Cellular Component	level 3: cytoplasm level 5: nucleus level 5: nucleolus
External source	Open in SGD