S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Ira1p
Description	GTPase-activating protein; negatively regulates RAS by converting it from GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; mutations cause catalase T deficiency, defective glycogen synthesis and defective trehalose accumulation; IRA1 has a paralog, IRA2, that arose from the whole genome duplication; defects in human homolog NF1 are associated with neurofibromatosis
GO Terms: Biological Process	level 3: signal transduction level 6: adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway level 6: regulation of GTPase activity level 6: regulation of adenylate cyclase activity level 7: positive regulation of GTPase activity level 9: negative regulation of Ras protein signal transduction
GO Terms: Molecular Function	level 5: GTPase activator activity
GO Terms: Cellular Component	level 3: cytoplasm level 3: membrane level 4: mitochondrion
External source	Open in SGD