S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Cdc28p
Description	Cyclin-dependent kinase (CDK) catalytic subunit; master regulator of mitotic and meiotic cell cycles; alternately associates with G1, S, G2/M phase cyclins, which provide substrate specificity; regulates metabolism, basal transcription, chromosome dynamics, growth and morphogenesis; transcript induction in osmostress involves antisense RNA; human homologs CDK1, CDK2, CDK3 can complement yeast conditional cdc28 mutants; human CDK1, CDK2 can complement yeast cdc28 null mutant
GO Terms: Biological Process	level 3: cell cycle level 3: signal transduction level 3: cell division level 4: meiotic DNA double-strand break processing level 5: regulation of filamentous growth level 5: mitotic sister chromatid biorientation level 5: synaptonemal complex assembly level 5: G1/S transition of mitotic cell cycle level 5: protein catabolic process level 5: regulation of budding cell apical bud growth level 6: telomere maintenance level 6: regulation of protein localization level 6: positive regulation of meiotic cell cycle level 6: DNA double-strand break processing level 6: negative regulation of meiotic cell cycle level 6: protein phosphorylation level 6: mitotic spindle assembly level 6: phosphorylation level 6: regulation of gene expression level 7: protein localization to nucleus level 7: regulation of spindle assembly level 7: post-Golgi vesicle-mediated transport level 7: positive regulation of trehalose catabolic process level 7: negative regulation of DNA replication origin binding level 7: negative regulation of mitotic cell cycle level 7: positive regulation of mitotic cell cycle level 7: regulation of protein localization to chromatin level 8: double-strand break repair via nonhomologous end joining level 8: protein localization to nuclear periphery level 8: 7-methylguanosine mRNA capping level 8: positive regulation of nuclear cell cycle DNA replication level 8: positive regulation of mitotic spindle pole body separation level 8: positive regulation of glycogen catabolic process level 8: positive regulation of triglyceride catabolic process level 8: negative regulation of sister chromatid cohesion level 8: negative regulation of DNA-templated transcription level 8: positive regulation of DNA-templated transcription level 8: regulation of G2/M transition of mitotic cell cycle level 8: negative regulation of mitotic actomyosin contractile ring assembly level 8: positive regulation of mitotic DNA damage checkpoint level 8: regulation of telomere maintenance via telomerase level 9: negative regulation of double-strand break repair via nonhomologous end joining level 9: negative regulation of transcription by RNA polymerase II level 9: positive regulation of transcription by RNA polymerase II level 9: positive regulation of double-strand break repair via homologous recombination level 10: protein localization to spindle microtubule
GO Terms: Molecular Function	level 3: transferase activity level 4: histone binding level 4: protein kinase activity level 4: nucleotide binding level 4: cyclin binding level 5: protein serine/threonine kinase activity level 5: kinase activity level 6: RNA polymerase II complex binding level 6: cyclin-dependent protein serine/threonine kinase activity level 6: ATP binding
GO Terms: Cellular Component	level 3: cytoplasm level 4: endoplasmic reticulum level 4: cellular bud neck level 5: nucleus level 5: cytoplasmic stress granule level 8: cyclin-dependent protein kinase holoenzyme complex
External source	Open in SGD