S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Atg12p
Description	Ubiquitin-like modifier involved in autophagy and the Cvt pathway; conserved; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg5p-Atg12p conjugate enhances E2 activity of Atg3p by rearranging its catalytic site, also forms a complex with Atg16p; the Atg5-Atg12/Atg16 complex binds to membranes and is essential for autophagosome formation; homolog of mammalian ULK1
GO Terms: Biological Process	level 4: autophagy level 4: regulation of catalytic activity level 4: cytoplasm to vacuole transport by the Cvt pathway level 5: autophagy of nucleus level 5: protein transport level 5: autophagy of mitochondrion level 6: piecemeal microautophagy of the nucleus level 6: late nucleophagy level 7: C-terminal protein lipidation level 7: autophagosome assembly level 8: protein lipidation involved in autophagosome assembly
GO Terms: Molecular Function	level 2: protein tag level 4: enzyme activator activity level 5: Atg8 ligase activity
GO Terms: Cellular Component	level 3: cytosol level 3: membrane level 3: phagophore assembly site level 3: cytoplasm level 4: phagophore assembly site membrane level 4: Atg12-Atg5-Atg16 complex
External source	Open in SGD