S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Tdp1p
Description	Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topo I and topo II; mutations in the human homolog, TDP1, result in the a neurodegenerative disease, spinocerebellar ataxia with axonal neuropathy (SCAN1); yeast cells and human rhabdomyosarcoma lines that overexpress TDP1 both exhibit elevated dosage chromosomal instability (dCIN)
GO Terms: Biological Process	level 5: cellular response to DNA damage stimulus level 6: nucleic acid phosphodiester bond hydrolysis level 6: DNA repair level 7: double-strand break repair level 7: single strand break repair
GO Terms: Molecular Function	level 3: hydrolase activity level 5: nuclease activity level 6: 5'-tyrosyl-DNA phosphodiesterase activity level 6: exonuclease activity level 6: phosphoric diester hydrolase activity level 6: double-stranded DNA binding level 6: 3'-tyrosyl-DNA phosphodiesterase activity level 6: single-stranded DNA binding
GO Terms: Cellular Component	level 4: mitochondrion level 5: nucleus
External source	Open in SGD