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Gene Ontology Information

Protein Name Rrt2p
Description Methylesterase performing penultimate step of diphthamide biosynthesis; hydrolyzes methylated diphthine to produce diphthine and allows Dph6-catalyzed amidation reaction to occur; deletion leads to resistance to sordarin and accumulation of methylatediphthine; WD40 domain-containing protein; involved in endosomal recycling; forms complex with Rtt10p that functions in retromer-mediated pathway for recycling internalized cell-surface proteins
GO Terms:
Biological Process		 level 5: peptidyl-diphthamide biosynthetic process from peptidyl-histidine external link
level 6: endocytic recycling external link
GO Terms:
Molecular Function		 level 3: hydrolase activity external link
level 6: diphthine methylesterase activity external link
GO Terms:
Cellular Component		 level 3: cytoplasm external link
level 4: endosome external link
External source Open in SGD external link
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