S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Mcd1p
Description	Essential alpha-kleisin subunit of the cohesin complex; required for sister chromatid cohesion in mitosis; subject to proteolytic cleavage by separase Esp1p, resulting in dissociation of cohesin from chromatin and the separation of sister chromatids at the mitotic metaphase-to-anaphase transition; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase
GO Terms: Biological Process	level 3: cell division level 3: cell cycle level 3: chromosome segregation level 4: response to oxidative stress level 4: sister chromatid cohesion level 5: mitotic sister chromatid cohesion level 5: mitotic chromosome condensation level 5: apoptotic process level 5: establishment of mitotic sister chromatid cohesion level 5: cellular response to DNA damage stimulus level 7: double-strand break repair level 9: replication-born double-strand break repair via sister chromatid exchange
GO Terms: Molecular Function	level 3: chromatin binding level 6: protein kinase binding
GO Terms: Cellular Component	level 4: chromosome, centromeric region level 4: cohesin complex level 4: mitochondrion level 5: nucleus level 5: chromosome level 5: mitotic cohesin complex level 6: condensed nuclear chromosome
External source	Open in SGD