S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Cdc7p
Description	Ser/Thr kinase and catalytic subunit of DDK (Dbf4-dependent kinase); required for origin firing and replication initiation; phosphorylates MCM subunits and Cdc45p to drive assembly of the pre-IC and the replicative CMG helicase (Cdc45-MCM-GINS); regulates pre-meiotic DNA replication, meiotic DSB formation, monopolar attachment of homologs during MI by recruiting monopolin to kinetochores, and regulation of middle meiotic genes including NDT80; complemented by co-expression of human CDC7 and DBF4
GO Terms: Biological Process	level 3: protein-containing complex localization level 3: cell division level 3: cell cycle level 3: meiotic cell cycle level 3: signal transduction level 4: positive regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination level 4: premeiotic DNA replication level 5: mitotic DNA replication checkpoint signaling level 5: mitotic DNA replication preinitiation complex assembly level 5: positive regulation of monopolar spindle attachment to meiosis I kinetochore level 6: DNA replication initiation level 6: protein phosphorylation level 6: phosphorylation level 7: peptidyl-serine phosphorylation level 7: positive regulation of protein localization to kinetochore level 8: positive regulation of meiosis I level 9: double-strand break repair via break-induced replication level 9: negative regulation of exit from mitosis
GO Terms: Molecular Function	level 3: transferase activity level 4: nucleotide binding level 4: protein kinase activity level 5: metal ion binding level 5: kinase activity level 5: protein serine/threonine kinase activity level 6: ATP binding
GO Terms: Cellular Component	level 3: cytoplasm level 3: chromatin level 4: Dbf4-dependent protein kinase complex level 4: chromosome, centromeric region level 5: nucleus
External source	Open in SGD