S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Bre1p
Description	E3 ubiquitin ligase; forms heterodimer with Rad6p to regulate K63 polyubiquitination in response to oxidative stress and to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control; interacts with RNA-binding protein Npl3p, linking histone ubiquitination to mRNA processing; Bre1p-dependent histone ubiquitination promotes pre-mRNA splicing
GO Terms: Biological Process	level 5: meiotic DNA double-strand break formation level 5: chromatin organization level 6: mitotic G1 DNA damage checkpoint signaling level 6: mitotic intra-S DNA damage checkpoint signaling level 7: telomere maintenance via recombination level 7: histone ubiquitination level 8: histone monoubiquitination level 8: protein ubiquitination level 8: double-strand break repair via homologous recombination level 8: subtelomeric heterochromatin formation level 8: transcription by RNA polymerase II level 9: histone H2B conserved C-terminal lysine ubiquitination level 9: regulation of DNA-templated DNA replication initiation level 10: protein K63-linked ubiquitination
GO Terms: Molecular Function	level 3: transferase activity level 5: metal ion binding level 5: ubiquitin-protein transferase activity level 6: ubiquitin protein ligase activity level 7: zinc ion binding level 8: DNA replication origin binding
GO Terms: Cellular Component	level 3: chromatin level 4: chromosome, telomeric region level 4: HULC complex level 5: nucleus
External source	Open in SGD