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Gene Ontology Information

Protein Name Kin28p
Description Ser/Thr protein kinase and subunit of TFIIK, a TFIIH subassembly; phosphorylates the C-terminal domain (CTD) of RNAPII (Ser5 and Ser7); facilitates recruitment of mRNA 5'-capping and polyadenylation factors to the RNAPII holoenzyme complex; minor role in RNAPII transcription; role in RNAPI transcription; regulates Atg1p kinase complex assembly during nitrogen starvation induced autophagy; associates with cyclin Ccl1p; relocalizes to the cytosol in response to hypoxia; ortholog of human CDK7
GO Terms:
Biological Process
level 3: cell division external link
level 3: cell cycle external link
level 5: regulation of cell cycle external link
level 6: protein phosphorylation external link
level 6: cellular response to nitrogen starvation external link
level 6: phosphorylation external link
level 7: phosphorylation of RNA polymerase II C-terminal domain external link
level 8: transcription by RNA polymerase I external link
level 8: transcription by RNA polymerase II external link
level 8: 7-methylguanosine mRNA capping external link
level 8: phosphorylation of RNA polymerase II C-terminal domain serine 5 residues involved in recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex external link
level 8: phosphorylation of RNA polymerase II C-terminal domain involved in recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex external link
level 8: positive regulation of autophagy external link
level 8: positive regulation of Atg1/ULK1 kinase complex assembly external link
level 9: positive regulation of transcription by RNA polymerase II external link
level 9: phosphorylation of RNA polymerase II C-terminal domain serine 5 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter external link
GO Terms:
Molecular Function
level 3: transferase activity external link
level 4: nucleotide binding external link
level 4: protein kinase activity external link
level 5: protein serine/threonine kinase activity external link
level 5: kinase activity external link
level 6: cyclin-dependent protein serine/threonine kinase activity external link
level 6: ATP binding external link
level 6: RNA polymerase II CTD heptapeptide repeat kinase activity external link
GO Terms:
Cellular Component
level 3: cytoplasm external link
level 3: cytosol external link
level 5: transcription factor TFIIK complex external link
level 5: nucleus external link
level 5: transcription factor TFIIH holo complex external link
External source Open in SGD external link
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