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Gene Ontology Information

Protein Name Grx3p
Description Glutathione-dependent oxidoreductase; hydroperoxide and superoxide-radical responsive monothiol glutaredoxin subfamily member with Grx4p and Grx5p; redundantly protects cells from oxidative damage along with GRX4 and GRX5; with Grx4p, promotes the dissociation of Aft1p from iron regulon gene promoters and subsequent nuclear export in iron-replete conditions, regulating iron homeostasis; involved with Grx4p in the deglutathionylation of Sir2p, restoring deacetylase activity after disulfide stress
GO Terms:
Biological Process
level 4: actin cytoskeleton organization external link
level 5: cellular response to oxidative stress external link
level 7: negative regulation of transcription regulatory region DNA binding external link
level 9: cellular iron ion homeostasis external link
level 10: positive regulation of histone deacetylation external link
GO Terms:
Molecular Function
level 4: iron-sulfur cluster binding external link
level 5: 2 iron, 2 sulfur cluster binding external link
level 5: glutathione oxidoreductase activity external link
level 5: disulfide oxidoreductase activity external link
level 5: metal ion binding external link
level 6: RNA polymerase II-specific DNA-binding transcription factor binding external link
GO Terms:
Cellular Component
level 3: cytosol external link
level 5: nucleus external link
External source Open in SGD external link
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