S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Ste5p
Description	Pheromone-responsive MAPK scaffold protein; couples activation of the G-protein-coupled pheromone receptor to MAPK activation; intramolecular interaction of PH and VWA domains blocks activation of assembled signaling cascade components (Ste11p, Ste7p and Fus3p) under basal conditions; Gbeta-gamma (Ste4p-Ste18p)-dependent docking at the plasma membrane and binding of PI(4,5)P2 by the PH domain relieves autoinhibition, resulting in pheromone-dependent pathway activation
GO Terms: Biological Process	level 5: response to pheromone level 5: pheromone-dependent signal transduction involved in conjugation with cellular fusion level 6: regulation of transposition, RNA-mediated level 7: invasive growth in response to glucose limitation level 8: negative regulation of MAPK cascade level 8: positive regulation of MAPK cascade level 9: positive regulation of protein phosphorylation
GO Terms: Molecular Function	level 4: G-protein beta-subunit binding level 5: MAP-kinase scaffold activity level 5: phosphatidylinositol-4,5-bisphosphate binding level 5: kinase binding
GO Terms: Cellular Component	level 3: cytoplasm level 4: mating projection tip level 4: plasma membrane level 5: mating projection tip membrane level 5: nucleus
External source	Open in SGD