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Gene Ontology Information

Protein Name Scc2p
Description Subunit of cohesin loading factor (Scc2p-Scc4p); a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; promotes gene expression program that supports translational fidelity; evolutionarily-conserved adherin; relocalizes to cytosol in response to hypoxia; human disorder Cornelia de Lange syndrome is caused by mutations in NIPBL, the human ortholog of SCC2; conserved role in NHEJ
GO Terms:
Biological Process
level 3: cell cycle external link
level 4: response to oxidative stress external link
level 5: 2-micrometer plasmid partitioning external link
level 5: establishment of mitotic sister chromatid cohesion external link
level 5: mitotic cohesin loading external link
level 5: mitotic chromosome condensation external link
level 6: rDNA chromatin condensation external link
level 6: regulation of gene expression external link
level 7: tRNA gene clustering external link
level 7: double-strand break repair external link
level 7: establishment of protein localization to chromatin external link
level 7: transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery external link
level 8: protein localization to chromatin external link
level 9: replication-born double-strand break repair via sister chromatid exchange external link
GO Terms:
Molecular Function
level 3: chromatin binding external link
level 3: kinetochore binding external link
GO Terms:
Cellular Component
level 3: cytosol external link
level 3: chromatin external link
level 4: SMC loading complex external link
level 4: chromosome, centromeric region external link
level 5: nucleus external link
level 5: chromosome external link
level 5: 2-micrometer circle DNA external link
level 5: Scc2-Scc4 cohesin loading complex external link
External source Open in SGD external link
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