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Gene Ontology Information

Protein Name Hel2p
Description RING finger ubiquitin ligase (E3); subunit of ribosome-associated quality control trigger complex (RQT); involved in ubiquitination and degradation of excess histones; interacts with Ubc4p and Rad53p; required to trigger ribosome-associated quality control (RQC) and canonical no-go decay; ubiquitinates Rps20 and Rps3; binds to ribosomal RNA, mRNA and tRNA
GO Terms:
Biological Process		 level 6: histone catabolic process external link
level 6: mRNA destabilization external link
level 7: rescue of stalled ribosome external link
level 7: negative regulation of gene expression external link
level 7: histone ubiquitination external link
level 8: protein ubiquitination external link
GO Terms:
Molecular Function		 level 3: transferase activity external link
level 5: ribosome binding external link
level 5: metal ion binding external link
level 6: ubiquitin protein ligase activity external link
level 7: zinc ion binding external link
GO Terms:
Cellular Component		 level 3: cytoplasm external link
External source Open in SGD external link
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