S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Vps74p
Description	Golgi PI4K effector, PtdIns4P sensor, and retention receptor; interacts with glycosyltransferases, and in the PtdIns4P-bound state mediates retention of these enzymes in the Golgi; PtdIns4P sensor that limits PI4K signaling and regulates lipid homeostasis, interacting with the catalytic domain of Sac1p, the major PtdIns4P phosphatase, directing dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; contributes to telomere function; ortholog of human GOLPH3
GO Terms: Biological Process	level 4: endoplasmic reticulum unfolded protein response level 5: protein retention in Golgi apparatus level 5: protein transport level 6: Golgi to plasma membrane protein transport level 6: Golgi organization level 6: regulation of phosphatidylinositol dephosphorylation level 7: retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum level 7: Golgi vesicle budding
GO Terms: Molecular Function	level 3: lipid binding level 4: enzyme binding level 7: phosphatidylinositol-4-phosphate binding
GO Terms: Cellular Component	level 3: cytoplasm level 3: cytosol level 3: membrane level 3: extrinsic component of membrane level 4: Golgi apparatus level 5: Golgi cisterna level 5: trans-Golgi network level 5: Golgi cisterna membrane level 5: Golgi membrane level 5: nucleus level 6: Golgi medial cisterna
External source	Open in SGD