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Gene Ontology Information

Protein Name Siz1p
Description SUMO E3 ligase; promotes attachment of small ubiquitin-related modifier sumo (Smt3p) to primarily cytoplasmic proteins; regulates Rsp5p ubiquitin ligase activity and is in turn itself regulated by Rsp5p; required for sumoylation of septins and histone H3 variant Cse4p, a prerequisite for STUbL-mediated Ub-dependent degradation; localizes to the septin ring; acts as an adapter between E2, Ubc9p and substrates; tends to compensate for survival of DNA damage in absence of Nfi1p
GO Terms:
Biological Process
level 3: chromosome segregation external link
level 5: DNA double-strand break attachment to nuclear envelope external link
level 8: protein sumoylation external link
level 10: negative regulation of protein ubiquitination external link
GO Terms:
Molecular Function
level 3: transferase activity external link
level 5: SUMO transferase activity external link
level 5: metal ion binding external link
level 6: double-stranded DNA binding external link
level 7: zinc ion binding external link
GO Terms:
Cellular Component
level 3: chromatin external link
level 3: cytoplasm external link
level 4: cellular bud neck external link
level 5: septin ring external link
level 5: nucleus external link
External source Open in SGD external link
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