S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Dot1p
Description	Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response; single DOT1 gene produces two Dot1p isoforms from alternative translation start sites as a result of leaky scanning by the ribosome
GO Terms: Biological Process	level 3: methylation level 5: meiotic recombination checkpoint signaling level 5: regulation of cell cycle level 5: chromatin organization level 6: regulation of transcription regulatory region DNA binding level 6: DNA repair level 6: mitotic G1 DNA damage checkpoint signaling level 6: mitotic intra-S DNA damage checkpoint signaling level 6: nucleosome assembly level 6: DNA damage checkpoint signaling level 7: nucleotide-excision repair level 7: postreplication repair level 7: recombinational repair level 8: global genome nucleotide-excision repair level 8: negative regulation of heterochromatin formation level 8: subtelomeric heterochromatin formation level 8: histone H3-K79 methylation level 8: histone exchange
GO Terms: Molecular Function	level 3: transferase activity level 4: histone binding level 5: DNA binding level 5: methyltransferase activity level 6: histone-lysine N-methyltransferase activity level 7: histone methyltransferase activity (H3-K79 specific)
GO Terms: Cellular Component	level 4: chromosome, telomeric region level 4: nucleosome level 5: nucleus
External source	Open in SGD