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Gene Ontology Information

Protein Name Mms21p
Description Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex; required for anchoring dsDNA breaks to the nuclear periphery; SMC5-SMC6 plays a key role in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; required for efficient sister chromatid cohesion; mutants are sensitive to MMS, show increased spontaneous mutation and mitotic recombination; SUMOylates and inhibits Snf1p function; supports nucleolar function
GO Terms:
Biological Process
level 5: negative regulation of catalytic activity external link
level 5: DNA double-strand break attachment to nuclear envelope external link
level 5: cellular response to DNA damage stimulus external link
level 6: DNA repair external link
level 6: DNA recombination external link
level 8: protein sumoylation external link
level 8: double-strand break repair via homologous recombination external link
GO Terms:
Molecular Function
level 3: transferase activity external link
level 5: metal ion binding external link
level 5: SUMO transferase activity external link
level 6: SUMO ligase activity external link
level 7: zinc ion binding external link
level 7: protein serine/threonine kinase inhibitor activity external link
GO Terms:
Cellular Component
level 3: cytoplasm external link
level 4: nuclear envelope external link
level 5: nucleus external link
level 6: Smc5-Smc6 complex external link
External source Open in SGD external link
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