S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Isc1p
Description	Inositol phosphosphingolipid phospholipase C; hydrolyzes complex sphingolipids to produce ceramide; regulates the spindle assembly checkpoint upstream of PP2A-Cdc55; activates genes required for non-fermentable carbon source metabolism during the diauxic shift; mediates Na+ and Li+ halotolerance; activated by phosphatidylserine, cardiolipin and phosphatidylglycerol; mitochondrial outer membrane protein; ortholog of mammalian neutral sphingomyelinase type 2
GO Terms: Biological Process	level 4: lipid metabolic process level 5: sphingolipid metabolic process level 5: response to salt stress level 6: sphingolipid catabolic process level 7: ceramide biosynthetic process level 8: regulation of mitotic cell cycle spindle assembly checkpoint
GO Terms: Molecular Function	level 2: catalytic activity level 3: hydrolase activity level 5: metal ion binding level 6: phospholipase activity level 7: sphingomyelin phosphodiesterase activity level 8: inositol phosphosphingolipid phospholipase activity
GO Terms: Cellular Component	level 3: cell periphery level 3: membrane level 4: mitochondrion level 4: endoplasmic reticulum level 4: integral component of membrane level 5: endoplasmic reticulum membrane level 6: mitochondrial outer membrane level 7: integral component of mitochondrial outer membrane
External source	Open in SGD