S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Tpa1p
Description	Prolyl hydroxylase; catalyzes oxygen-dependent dihydroxylation of Rps23a/b, a 40S ribosomal decoding center subunit; influences translational termination and regulates translational accuracy; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; disputed role as a oxidative dealkylase repairing DNA methyl-base lesions; poly(rA)-binding protein affecting poly(A) tail length and mRNA stability; Fe(II)/2-oxoglutarate-dependent dioxygenase family member similar to human prolyl 4-hydroxylase OGFOD1
GO Terms: Biological Process	level 4: regulation of translational fidelity level 6: translational termination level 7: regulation of translational termination level 7: nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay level 7: peptidyl-proline hydroxylation level 8: peptidyl-proline di-hydroxylation
GO Terms: Molecular Function	level 3: oxidoreductase activity level 4: dioxygenase activity level 4: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen level 4: L-ascorbic acid binding level 4: peptidyl-proline dioxygenase activity level 5: metal ion binding level 5: 2-oxoglutarate-dependent dioxygenase activity level 7: iron ion binding level 8: poly(A) binding level 8: ferrous iron binding
GO Terms: Cellular Component	level 3: cytoplasm level 5: nucleus
External source	Open in SGD