S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Scs2p
Description	Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to plasma membrane (PM) and regulate PI4P levels by controlling access of Sac1p phosphatase to substrate PI4P in the PM; interacts with FFAT motifs in Opi1p, Swh1p, Osh2p, and Osh3p; involved in telomeric silencing; VAP homolog; SCS2 has a paralog, SCS22, that arose from the whole genome duplication
GO Terms: Biological Process	level 5: phospholipid biosynthetic process level 5: endoplasmic reticulum-plasma membrane tethering level 6: regulation of phosphatidylinositol dephosphorylation level 6: endoplasmic reticulum membrane organization level 7: endoplasmic reticulum inheritance level 7: endoplasmic reticulum polarization level 7: reticulophagy level 7: regulation of intracellular lipid transport level 8: negative regulation of protein import into nucleus level 8: subtelomeric heterochromatin formation
GO Terms: Molecular Function	level 5: FFAT motif binding level 5: phosphatidylinositol binding
GO Terms: Cellular Component	level 3: membrane level 4: cellular bud neck level 4: integral component of membrane level 4: chromosome, telomeric region level 4: nucleus-vacuole junction level 4: nuclear envelope level 4: endoplasmic reticulum level 4: plasma membrane level 4: cellular bud tip level 5: nucleus level 5: nuclear membrane level 5: endoplasmic reticulum membrane level 6: integral component of endoplasmic reticulum membrane
External source	Open in SGD