S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Rsp5p
Description	NEDD4 family E3 ubiquitin ligase; regulates processes including: MVB sorting, the heat shock response, transcription, endocytosis and ribosome stability; ubiquitinates Sec23p, Sna3p, Ste4p, Nfi1p, Rpo21p, Sem1p, Dip5p and Put4p; autoubiquitinates; deubiquitinated by Ubp2p; regulated by SUMO ligase Siz1p, in turn regulates Siz1p SUMO ligase activity; required for efficient Golgi-to-ER trafficking in COPI mutants; mutant tolerates aneuploidy; human homolog implicated in Liddle syndrome
GO Terms: Biological Process	level 4: response to xenobiotic stimulus level 5: chromatin organization level 5: free ubiquitin chain polymerization level 6: regulation of protein localization level 6: regulation of actin cytoskeleton organization level 6: mitochondrion organization level 6: ubiquitin-dependent endocytosis level 6: regulation of initiation of mating projection growth level 6: positive regulation of endocytosis level 7: protein quality control for misfolded or incompletely synthesized proteins level 7: positive regulation of receptor-mediated endocytosis level 7: poly(A)+ mRNA export from nucleus level 7: ribophagy level 7: regulation of phosphate metabolic process level 7: cellular response to UV level 7: regulation of mRNA export from nucleus level 7: proteasome-mediated ubiquitin-dependent protein catabolic process level 7: regulation of dolichol biosynthetic process level 7: regulation of rRNA processing level 7: regulation of tRNA processing level 7: regulation of ergosterol biosynthetic process level 7: regulation of tRNA export from nucleus level 7: late endosome to vacuole transport via multivesicular body sorting pathway level 8: protein ubiquitination level 8: regulation of nitrogen utilization level 8: mitochondria-associated ubiquitin-dependent protein catabolic process level 8: regulation of ribosomal large subunit export from nucleus level 8: regulation of ubiquinone biosynthetic process level 8: positive regulation of fatty acid biosynthetic process level 8: regulation of multivesicular body size level 8: ubiquitin-dependent protein catabolic process level 9: protein polyubiquitination level 9: protein monoubiquitination level 9: positive regulation of transcription by RNA polymerase II level 9: protein autoubiquitination level 9: positive regulation of proteasomal ubiquitin-dependent protein catabolic process level 9: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO Terms: Molecular Function	level 3: transferase activity level 5: ubiquitin-protein transferase activity level 5: phosphatidylinositol binding level 5: ubiquitin binding level 6: ubiquitin protein ligase activity level 7: ubiquitin-ubiquitin ligase activity
GO Terms: Cellular Component	level 3: cytoplasm level 4: mitochondrion level 4: actin cortical patch level 4: Golgi apparatus level 4: plasma membrane level 4: cellular bud tip level 4: ubiquitin ligase complex level 5: nucleus level 5: endosome membrane level 5: extrinsic component of cytoplasmic side of plasma membrane level 5: cytoskeleton
External source	Open in SGD