S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Rph1p
Description	JmjC domain-containing histone demethylase; targets tri- and dimethylated H3K36; associates with actively transcribed regions and promotes elongation; repressor of autophagy-related genes in nutrient-replete conditions; damage-responsive repressor of PHR1; phosphorylated by the Rad53p-dependent DNA damage checkpoint pathway and by a Rim1p-mediated event during starvation; target of stress-induced hormesis; RPH1 has a paralog, GIS1, that arose from the whole genome duplication
GO Terms: Biological Process	level 6: chromatin remodeling level 8: negative regulation of autophagy level 9: negative regulation of transcription by RNA polymerase II level 10: positive regulation of transcription elongation by RNA polymerase II
GO Terms: Molecular Function	level 5: histone demethylase activity level 5: metal ion binding level 5: DNA-binding transcription repressor activity, RNA polymerase II-specific level 5: DNA binding level 6: histone H3-methyl-lysine-9 demethylase activity level 6: sequence-specific DNA binding level 6: histone H3-methyl-lysine-36 demethylase activity level 7: zinc ion binding
GO Terms: Cellular Component	level 5: nucleus
External source	Open in SGD