S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Eco1p
Description	Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to dsDNA breaks; phosphorylated by three kinases (Cdc28p, Cdc7p, Mck1p) to generate pair of phosphates spaced precisely for recognition by ubiquitin ligase SCF-Cdc4; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to nucleus increases upon DNA replication stress
GO Terms: Biological Process	level 3: cell cycle level 4: response to oxidative stress level 4: establishment of meiotic sister chromatid cohesion level 4: sister chromatid cohesion level 4: meiotic chromosome segregation level 5: establishment of mitotic sister chromatid cohesion level 5: mitotic sister chromatid cohesion level 5: mitotic sister chromatid segregation level 5: mitotic chromosome condensation level 6: chromosome organization level 6: DNA replication level 6: chromatin looping level 6: DNA repair level 7: tRNA gene clustering level 7: double-strand break repair level 7: telomere organization level 9: internal peptidyl-lysine acetylation
GO Terms: Molecular Function	level 3: transferase activity level 4: peptide-lysine-N-acetyltransferase activity level 4: acyltransferase activity level 5: metal ion binding level 6: acetyltransferase activity level 7: zinc ion binding
GO Terms: Cellular Component	level 3: chromatin level 3: cytoplasm level 4: nuclear replication fork level 5: nucleus
External source	Open in SGD