S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Pnc1p
Description	Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; lacks a peroxisomal targeting signal but is imported into peroxisomes via binding to Gpd1p; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress
GO Terms: Biological Process	level 6: rDNA heterochromatin formation level 7: nicotinate nucleotide salvage level 7: pyridine nucleotide biosynthetic process level 8: subtelomeric heterochromatin formation level 9: negative regulation of DNA amplification
GO Terms: Molecular Function	level 3: hydrolase activity level 5: metal ion binding level 6: nicotinamidase activity level 7: zinc ion binding
GO Terms: Cellular Component	level 3: cytoplasm level 4: chromosome, telomeric region level 5: nucleus level 5: peroxisome
External source	Open in SGD