S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Xrn1p
Description	Evolutionarily-conserved 5'-3' exonuclease; component of cytoplasmic processing (P) bodies involved in mRNA decay; enters the nucleus and positively regulates transcription initiation and elongation; involved in microtubule-mediated processes, filamentous growth, ribosomal RNA maturation, telomere maintenance, and turnover of tRNA introns; negative regulator of autophagy; activated by the scavenger decapping enzyme Dcs1p; expression regulated by Ash1p in rich conditions
GO Terms: Biological Process	level 4: translational initiation level 5: positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus level 6: mRNA destabilization level 6: nucleic acid phosphodiester bond hydrolysis level 7: karyogamy level 7: regulation of telomere maintenance level 7: rRNA processing level 8: rRNA catabolic process level 8: tRNA catabolic process level 8: RNA phosphodiester bond hydrolysis, exonucleolytic level 8: nuclear-transcribed mRNA catabolic process level 8: NAD-cap decapping level 8: sno(s)RNA processing level 9: nonfunctional rRNA decay level 9: negative regulation of macroautophagy level 9: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay level 9: nuclear-transcribed mRNA catabolic process, no-go decay level 10: positive regulation of transcription initiation by RNA polymerase II level 10: nuclear-transcribed mRNA catabolic process, 5'-3' exonucleolytic nonsense-mediated decay level 10: positive regulation of transcription elongation by RNA polymerase II level 10: traversing start control point of mitotic cell cycle
GO Terms: Molecular Function	level 3: hydrolase activity level 3: chromatin binding level 4: nucleic acid binding level 5: nuclease activity level 5: eukaryotic initiation factor 4G binding level 5: RNA binding level 6: mRNA binding level 6: exonuclease activity level 7: 5'-3' exonuclease activity level 8: 5'-3' exoribonuclease activity
GO Terms: Cellular Component	level 3: cytoplasm level 3: perinuclear region of cytoplasm level 4: eisosome membrane domain/MCC level 5: cytoplasmic stress granule level 5: nucleus level 5: P-body level 7: microtubule
External source	Open in SGD