S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Sae2p
Description	Endonuclease required for telomere elongation; required for telomeric 5' C-rich strand resection; involved in ds-break repair and processing hairpin DNA structures with the MRX complex; function requires sumoylation and phosphorylation; exists as inactive oligomers that are transiently released into smaller active units by phosphorylation; DNA damage triggers Sae2p removal, so active Sae2p is present only transiently; sequence and functional similarity with human CtIP/RBBP8
GO Terms: Biological Process	level 3: meiotic cell cycle level 3: gene conversion at mating-type locus level 4: meiotic DNA double-strand break processing level 5: meiotic DNA double-strand break formation level 5: cellular response to DNA damage stimulus level 6: DNA repair level 6: telomere maintenance level 6: DNA double-strand break processing level 7: telomeric 3' overhang formation level 7: DNA double-strand break processing involved in repair via synthesis-dependent strand annealing level 7: DNA catabolic process, endonucleolytic level 8: positive regulation of exonuclease activity level 9: positive regulation of dephosphorylation
GO Terms: Molecular Function	level 3: hydrolase activity level 5: nuclease activity level 5: DNA binding level 6: endonuclease activity level 6: double-stranded DNA binding level 7: single-stranded DNA endodeoxyribonuclease activity
GO Terms: Cellular Component	level 3: cytoplasm level 4: Mre11 complex level 5: nucleus
External source	Open in SGD