S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Spt16p
Description	Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; specifically required for diauxic shift-induced H2B deposition onto rDNA genes; mutations cause reduced nucleosome occupancy over highly transcribed regions; coregulates transcription with Mot1p through preinitiation complex assembly and nucleosome organization
GO Terms: Biological Process	level 5: chromatin organization level 5: cellular response to DNA damage stimulus level 6: DNA repair level 6: nucleosome assembly level 6: DNA replication level 7: DNA-templated DNA replication level 7: regulation of sister chromatid cohesion level 8: positive regulation of RNA polymerase II transcription preinitiation complex assembly level 8: transcription elongation by RNA polymerase II promoter level 10: positive regulation of transcription initiation by RNA polymerase II level 10: positive regulation of transcription elongation by RNA polymerase II
GO Terms: Molecular Function	level 3: chromatin binding level 3: protein binding level 4: histone binding level 4: nucleosome binding
GO Terms: Cellular Component	level 3: chromatin level 4: replication fork protection complex level 4: FACT complex level 5: nucleus level 5: chromosome
External source	Open in SGD