S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Esp1p
Description	Separase/separin, a caspase-like cysteine protease; cleaves Mcd1p/Scc1p, a mitotic cohesin complex subunit, resulting in the dissociation of cohesin from chromatin and sister chromatid separation; cleaves meiotic-cohesin subunit Rec8p along chromosome arms in meiosis I and at centromeric sites during meiosis II; inhibits PP2A-Cdc55p to promote mitotic exit; inhibited by Pds1p (securin); relative distribution to the nucleus increases upon DNA replication stress
GO Terms: Biological Process	level 3: chromosome segregation level 4: meiotic chromosome separation level 5: proteolysis level 5: apoptotic process level 5: mitotic sister chromatid segregation level 7: regulation of mitotic spindle elongation level 8: negative regulation of protein localization to nucleolus level 8: negative regulation of phosphoprotein phosphatase activity level 9: positive regulation of exit from mitosis
GO Terms: Molecular Function	level 3: hydrolase activity level 4: peptidase activity level 5: cysteine-type peptidase activity level 6: cysteine-type endopeptidase activity
GO Terms: Cellular Component	level 3: cytoplasm level 4: mitochondrion level 4: spindle pole body level 5: spindle level 5: mitotic spindle pole body level 5: cytoskeleton level 5: nucleus level 6: mitotic spindle
External source	Open in SGD