S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Lsb1p
Description	Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with PIN3 cooperatively inhibits the nucleation of actin filaments; overexpression blocks receptor-mediated endocytosis; protein increases in abundance and forms nuclear foci in response to DNA replication stress; LSB1 has a paralog, PIN3, that arose from the whole genome duplication
GO Terms: Biological Process	level 6: protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway level 9: negative regulation of Arp2/3 complex-mediated actin nucleation
GO Terms: Molecular Function	level 1: molecular_function
GO Terms: Cellular Component	level 3: cytoplasm level 4: actin cortical patch level 4: ESCRT-0 complex level 5: cytoskeleton level 5: nucleus
External source	Open in SGD