S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Tif4631p
Description	Translation initiation factor eIF4G and scaffold protein; subunit of the mRNA cap-binding protein complex (eIF4F) with eIF4E (Cdc33p) and eIF4A (Tif1p/Tif2p); stimulates the ATPase and helicase activities of eIF4A synergistically with eIF4G; required with eIF4E for Ded1p-mediated stimulation of mRNA recruitment during 48S preinitiation complex (PIC) assembly; association with Pab1p mediates poly(A) tail-stimulated translation; role in biogenesis of the 60S ribosomal subunit
GO Terms: Biological Process	level 4: translational initiation level 5: translation level 6: ribosomal large subunit biogenesis level 6: regulation of RNA helicase activity level 7: regulation of translation level 8: positive regulation of formation of translation preinitiation complex level 8: stress granule assembly
GO Terms: Molecular Function	level 3: protein binding level 4: ATPase activator activity level 5: translation initiation factor activity level 5: RNA binding level 6: mRNA binding
GO Terms: Cellular Component	level 3: cytoplasm level 3: eukaryotic translation initiation factor 4F complex level 4: mitochondrion level 5: P-body level 5: cytoplasmic stress granule
External source	Open in SGD