S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Bub1p
Description	Protein kinase involved in the cell cycle checkpoint into anaphase; in complex with Mad1p and Bub3p, prevents progression into anaphase in presence of spindle damage; Cdc28p-mediated phosphorylation at Bub1p-T566 is important for degradation in anaphase and adaptation of checkpoint to prolonged mitotic arrest; associates with centromere DNA via Skp1p; involved in Sgo1p relocalization in response to sister kinetochore tension; paralog MAD3 arose from whole genome duplication
GO Terms: Biological Process	level 3: cell cycle level 5: mitotic spindle assembly checkpoint signaling level 5: macroautophagy level 5: sister chromatid biorientation level 6: meiotic sister chromatid cohesion, centromeric level 6: protein phosphorylation level 6: phosphorylation level 7: centromere complex assembly level 9: protein localization to kinetochore
GO Terms: Molecular Function	level 3: protein binding level 3: transferase activity level 4: nucleotide binding level 4: protein kinase activity level 5: kinase activity level 5: protein serine/threonine kinase activity level 6: ATP binding
GO Terms: Cellular Component	level 4: kinetochore level 5: nucleus level 5: condensed chromosome, centromeric region
External source	Open in SGD