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Gene Ontology Information
Locus Info
Protein Info
GO Info
Orthologs
Metabolism
Protein Name
Fol2p
Description
GTP-cyclohydrolase I, catalyzes first step in folic acid biosynthesis; human homolog GCH1 is implicated in dopa-responsive dystonia (DRD), and can complement yeast null mutant
GO Terms:
Biological Process
level 2:
metabolic process
level 6:
folic acid-containing compound biosynthetic process
level 6:
7,8-dihydroneopterin 3'-triphosphate biosynthetic process
level 7:
tetrahydrobiopterin biosynthetic process
level 7:
tetrahydrofolate biosynthetic process
level 7:
folic acid biosynthetic process
GO Terms:
Molecular Function
level 2:
catalytic activity
level 3:
hydrolase activity
level 4:
nucleotide binding
level 5:
metal ion binding
level 6:
GTP binding
level 7:
zinc ion binding
level 8:
GTP cyclohydrolase I activity
GO Terms:
Cellular Component
level 3:
cytoplasm
level 5:
nucleus
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