S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Spo11p
Description	Meiosis-specific protein required for meiotic recombination; makes DNA double-strand breaks (DSB) during meiotic recombination, homolog pairing, and synaptonemal complex formation; role in meiotic DSB formation involves a topo-II-like transesterase mechanism; forms monotetrameric complex; covalently linked to DSBs through a 5'-phosphodiester bond between a catalytic tyrosine (Y135) and the DSB 5'- end; sequence similarity to a topo VI subunit from archaea, fission yeast rec12 and human SPO11
GO Terms: Biological Process	level 3: meiotic cell cycle level 4: sporulation resulting in formation of a cellular spore level 4: meiotic DNA double-strand break processing level 4: reciprocal meiotic recombination level 5: meiotic DNA double-strand break formation level 5: DNA metabolic process level 5: homologous chromosome pairing at meiosis level 5: synaptonemal complex assembly
GO Terms: Molecular Function	level 2: catalytic activity level 3: hydrolase activity level 3: chromatin binding level 3: isomerase activity level 4: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity level 5: metal ion binding level 5: DNA binding level 6: ATP binding level 6: DNA end binding
GO Terms: Cellular Component	level 5: nucleus level 5: chromosome level 6: nuclear chromosome level 6: condensed nuclear chromosome
External source	Open in SGD