S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Ire1p
Description	Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; role in homeostatic adaptation to ER stress; Kar2p binds inactive Ire1p and releases from it upon ER stress
GO Terms: Biological Process	level 2: metabolic process level 4: endoplasmic reticulum unfolded protein response level 5: fungal-type cell wall organization level 5: response to unfolded protein level 5: response to endoplasmic reticulum stress level 5: IRE1-mediated unfolded protein response level 5: inositol metabolic process level 6: protein phosphorylation level 6: phosphorylation level 6: intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress level 7: protein localization to Golgi apparatus level 7: mRNA processing level 8: RNA phosphodiester bond hydrolysis, endonucleolytic
GO Terms: Molecular Function	level 2: catalytic activity level 3: transferase activity level 3: hydrolase activity level 4: protein kinase activity level 4: unfolded protein binding level 4: nucleotide binding level 5: ribonuclease activity level 5: protein serine/threonine kinase activity level 5: metal ion binding level 5: kinase activity level 6: endoribonuclease activity level 6: ATP binding
GO Terms: Cellular Component	level 3: membrane level 4: integral component of membrane level 4: endoplasmic reticulum level 4: IRE1-TRAF2-ASK1 complex level 5: nucleus level 5: endoplasmic reticulum membrane level 6: integral component of endoplasmic reticulum membrane
External source	Open in SGD