S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Set1p
Description	Histone methyltransferase, subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3K4; Set1p-dependent H3K4 trimethylation recruits Nrd1p, allowing efficient termination of snoRNAs and cryptic unstable transcripts (CUTs) by Nrd1p-Nab3p-Sen1p pathway; modulates histone acetylation levels in promoter proximal regions to ensure efficient Nrd1p-dependent termination; required in transcriptional silencing near telomeres and at silent mating type loci; has a SET domain
GO Terms: Biological Process	level 3: methylation level 4: ascospore formation level 5: regulation of meiotic DNA double-strand break formation level 5: chromatin organization level 5: meiotic DNA double-strand break formation level 6: regulation of chromatin organization level 6: telomere maintenance level 7: histone lysine methylation level 8: subtelomeric heterochromatin formation level 8: regulation of transcription by RNA polymerase II level 8: histone H3-K4 methylation level 9: positive regulation of transcription by RNA polymerase II level 9: negative regulation of transcription by RNA polymerase II level 10: silent mating-type cassette heterochromatin formation level 10: positive regulation of histone acetylation
GO Terms: Molecular Function	level 3: transferase activity level 5: RNA binding level 5: methyltransferase activity level 5: protein-lysine N-methyltransferase activity level 6: histone-lysine N-methyltransferase activity level 7: zinc ion binding level 7: histone methyltransferase activity (H3-K4 specific)
GO Terms: Cellular Component	level 5: nucleus level 5: chromosome level 5: Set1C/COMPASS complex
External source	Open in SGD