S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Mnl1p
Description	Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; involved in glycan trimming of both folded and misfolded glycoproteins; complexes with Pdi1p, and trims a mannose from Man8GlcNac2 glycans to generate Man7GlcNac2, an oligosaccharide signal on glycoproteins destined for ER-associated protein degradation; requires Pdi1p for stability and substrate recognition; human homolog EDEM1 can complement yeast null mutant
GO Terms: Biological Process	level 2: metabolic process level 4: carbohydrate metabolic process level 5: protein glycosylation level 5: response to unfolded protein level 6: ubiquitin-dependent glycoprotein ERAD pathway level 7: mannose trimming involved in glycoprotein ERAD pathway level 8: protein alpha-1,2-demannosylation level 9: endoplasmic reticulum mannose trimming
GO Terms: Molecular Function	level 3: hydrolase activity level 3: carbohydrate binding level 4: hydrolase activity, acting on glycosyl bonds level 5: metal ion binding level 6: calcium ion binding level 7: alpha-mannosidase activity level 9: mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO Terms: Cellular Component	level 3: membrane level 3: endoplasmic reticulum quality control compartment level 4: endoplasmic reticulum level 5: endoplasmic reticulum lumen
External source	Open in SGD