S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Mtr4p
Description	RNA duplex-sensing translocase; ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing
GO Terms: Biological Process	level 6: RNA catabolic process level 7: rRNA processing level 7: mRNA processing level 8: maturation of 5.8S rRNA level 8: ncRNA polyadenylation level 8: rRNA catabolic process level 8: nuclear polyadenylation-dependent mRNA catabolic process level 9: exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) level 9: nuclear mRNA surveillance level 9: nuclear polyadenylation-dependent rRNA catabolic process level 9: nuclear polyadenylation-dependent tRNA catabolic process level 9: U4 snRNA 3'-end processing level 9: U5 snRNA 3'-end processing level 10: nuclear mRNA surveillance of mRNA 3'-end processing level 10: polyadenylation-dependent snoRNA 3'-end processing
GO Terms: Molecular Function	level 2: catalytic activity level 3: oxidoreductase activity level 3: hydrolase activity level 3: helicase activity level 4: nucleic acid binding level 4: RNA helicase activity level 4: nucleotide binding level 5: RNA binding level 5: 3'-5' RNA helicase activity level 6: mRNA binding level 6: ATP binding level 8: poly(A) binding
GO Terms: Cellular Component	level 4: TRAMP complex level 5: nucleus level 5: nucleolus
External source	Open in SGD