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Gene Ontology Information

Protein Name Far1p
Description CDK inhibitor and nuclear anchor; during the cell cycle Far1p sequesters the GEF Cdc24p in the nucleus; phosphorylation by Cdc28p-Cln results in SCFCdc4 complex-mediated ubiquitin-dependent degradation, releasing Cdc24p for export and activation of GTPase Cdc42p; in response to pheromone, phosphorylation of Far1p by MAPK Fus3p results in association with, and inhibition of Cdc28p-Cln, as well as Msn5p mediated nuclear export of Far1p-Cdc24p, targeting Cdc24p to polarity sites
GO Terms:
Biological Process
level 3: cell division external link
level 3: cell cycle external link
level 4: chemotropism external link
level 5: negative regulation of catalytic activity external link
level 6: maintenance of protein location in nucleus external link
level 7: negative regulation of cyclin-dependent protein serine/threonine kinase activity external link
level 8: mitotic cell cycle G1 arrest in response to pheromone external link
GO Terms:
Molecular Function
level 5: metal ion binding external link
level 6: protein kinase inhibitor activity external link
level 7: cyclin-dependent protein serine/threonine kinase inhibitor activity external link
level 7: zinc ion binding external link
GO Terms:
Cellular Component
level 3: Cdc24p-Far1p-Gbetagamma complex external link
level 3: cytoplasm external link
level 4: mating projection tip external link
level 5: nucleus external link
External source Open in SGD external link
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