S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Cbf1p
Description	Basic helix-loop-helix (bHLH) protein; forms homodimer to bind E-box consensus sequence CACGTG present at MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins, required for chromosome segregation; protein abundance increases in response to DNA replication stress
GO Terms: Biological Process	level 3: chromosome segregation level 6: chromatin remodeling level 8: ncRNA transcription level 8: regulation of transcription by RNA polymerase II level 9: negative regulation of transcription by RNA polymerase II level 9: positive regulation of transcription by RNA polymerase II
GO Terms: Molecular Function	level 3: DNA-binding transcription factor activity level 4: protein dimerization activity level 5: DNA binding level 5: DNA-binding transcription repressor activity, RNA polymerase II-specific level 5: DNA-binding transcription activator activity, RNA polymerase II-specific level 6: RNA polymerase II-specific DNA-binding transcription factor binding level 8: RNA polymerase II cis-regulatory region sequence-specific DNA binding level 8: centromeric DNA binding
GO Terms: Cellular Component	level 4: Cbf1-Met4-Met28 complex level 4: mitochondrion level 4: chromosome, centromeric region level 4: kinetochore level 5: nucleus level 5: chromosome
External source	Open in SGD