S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Ham1p
Description	Nucleoside triphosphate pyrophosphohydrolase; active against various substrates including ITP, dITP and XTP; mediates exclusion of non canonical purines, pyrimidines from dNTP pools; functions with YJL055W to mediate resistance to 5-FU; specifically reduces the incorporation of 5-FU into RNA without affecting uptake or incorporation of uracil into RNA; protein abundance increases in response to DNA replication stress; yeast HAM1 can complement knockdown of human homolog ITPA
GO Terms: Biological Process	level 6: nucleotide metabolic process level 7: nucleoside triphosphate catabolic process level 8: deoxyribonucleoside triphosphate catabolic process level 9: pyrimidine deoxyribonucleoside triphosphate catabolic process level 9: purine deoxyribonucleoside triphosphate catabolic process
GO Terms: Molecular Function	level 3: hydrolase activity level 4: nucleotide binding level 5: metal ion binding level 7: nucleoside triphosphate diphosphatase activity level 8: dCTP diphosphatase activity level 8: dITP diphosphatase activity level 8: dUTP diphosphatase activity level 8: dGTP diphosphatase activity level 8: dTTP diphosphatase activity level 8: GTP diphosphatase activity level 8: dATP diphosphatase activity level 8: ITP diphosphatase activity level 8: UTP diphosphatase activity level 8: XTP diphosphatase activity
GO Terms: Cellular Component	level 3: cytoplasm level 5: nucleus
External source	Open in SGD