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Gene Ontology Information

Protein Name Bna2p
Description Tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase; required for de novo biosynthesis of NAD+ from tryptophan via kynurenine; up-regulated by telomere uncapping, and interacts genetically with capping gene CDC13; overexpression reduces lipid droplet accumulation by skewing glycolytic flux towards biosynthesis of shikimate, aromatic amino acids, and NAD+ during aging and extends lifespan; regulated by Hst1p and Aftp
GO Terms:
Biological Process		 level 6: tryptophan catabolic process to kynurenine external link
level 7: 'de novo' NAD biosynthetic process from tryptophan external link
level 9: NAD biosynthetic process external link
GO Terms:
Molecular Function		 level 3: oxidoreductase activity external link
level 4: dioxygenase activity external link
level 5: metal ion binding external link
level 5: heme binding external link
level 6: indoleamine 2,3-dioxygenase activity external link
GO Terms:
Cellular Component		 level 3: cytoplasm external link
External source Open in SGD external link
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