S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Ste24p
Description	Highly conserved zinc metalloprotease; component of the ER quality control mechanism that removes faulty proteins clogging translocation channels; inhibits SRP-independent translocation into the ER; has two roles in a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; cleaves isoprenylated and non-prenylated oligopeptides; human homolog ZMPSTE24 implicated in mandibuloacral dysplasia (MAD), and complements the null mutant
GO Terms: Biological Process	level 5: proteolysis level 5: response to pheromone level 6: protein processing level 7: peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion level 7: CAAX-box protein processing level 7: ER-associated misfolded protein catabolic process level 7: negative regulation of post-translational protein targeting to membrane, translocation
GO Terms: Molecular Function	level 3: hydrolase activity level 4: peptidase activity level 5: metal ion binding level 5: metallopeptidase activity level 6: metalloendopeptidase activity level 7: zinc ion binding
GO Terms: Cellular Component	level 3: membrane level 4: endoplasmic reticulum level 4: integral component of membrane level 5: endoplasmic reticulum membrane level 6: integral component of endoplasmic reticulum membrane level 6: nuclear inner membrane level 6: mitochondrial outer membrane
External source	Open in SGD