S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Cse4p
Description	Centromeric histone H3-like protein; associates with promoters, accessible chromatin, and RNAPII-bound regions; phosphorylated Cse4p associates with centromeres; required for kinetochore function; Ipl1p-dependent phosphorylation destabilizes defective kinetochores promoting bi-orientation; increases association of Sgo1p with centromeric chromatin; proteolysis regulated by multiple E3 ligases, resulting in faithful chromosome segregation; CSE4 complements mutations in the human homolog CENPA
GO Terms: Biological Process	level 5: mitotic sister chromatid segregation level 5: 2-micrometer plasmid partitioning level 7: kinetochore assembly level 9: protein localization to CENP-A containing chromatin
GO Terms: Molecular Function	level 3: structural constituent of chromatin level 5: protein heterodimerization activity level 5: DNA binding level 6: sequence-specific DNA binding level 8: centromeric DNA binding
GO Terms: Cellular Component	level 4: kinetochore level 4: nucleosome level 4: chromosome, centromeric region level 5: condensed chromosome, centromeric region level 5: nucleus level 5: chromosome level 5: 2-micrometer circle DNA level 5: CENP-A containing nucleosome
External source	Open in SGD