S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Dbr1p
Description	RNA lariat debranching enzyme; catalyzes debranching of lariat introns formed during pre-mRNA splicing; required for efficient Ty1 transposition; knockdown of human homolog Dbr1 rescues toxicity of RNA-binding proteins TDP-43 and FUS which are implicated in amyotrophic lateral sclerosis (ALS), suggests potential therapeutic target for ALS and related TDP-43 proteinopathies; human homolog DBR1 can complement yeast dbr1 null mutant
GO Terms: Biological Process	level 4: pseudohyphal growth level 4: transposition, RNA-mediated level 6: RNA catabolic process level 7: mRNA processing level 8: mRNA splicing, via spliceosome level 8: RNA phosphodiester bond hydrolysis, endonucleolytic level 8: sno(s)RNA metabolic process
GO Terms: Molecular Function	level 3: hydrolase activity level 4: hydrolase activity, acting on ester bonds level 8: RNA lariat debranching enzyme activity
GO Terms: Cellular Component	level 3: cytoplasm level 5: nucleus
External source	Open in SGD