S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Tif1p
Description	Translation initiation factor eIF4A; DEAD-box RNA helicase that couples ATPase activity to mRNA binding and unwinding; ATP hydrolysis accelerates the recruitment of mRNA during 48S preinitiation complex (PIC) assembly; ATPase activity stimulated by either eIF4G1 or by the PIC in an eIF3g and eIFGi subunit-dependent manner, independent of eIF4E and eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) with eIF4E and eIF4G; protein abundance increases in response to DNA replication stress
GO Terms: Biological Process	level 4: translational initiation level 5: translation level 5: cytoplasmic translational initiation level 8: positive regulation of formation of translation preinitiation complex
GO Terms: Molecular Function	level 3: hydrolase activity level 3: helicase activity level 3: ATP-dependent activity, acting on RNA level 4: nucleic acid binding level 4: RNA helicase activity level 4: nucleotide binding level 5: RNA binding level 5: translation initiation factor activity level 6: ATP binding
GO Terms: Cellular Component	level 3: eukaryotic translation initiation factor 4F complex level 3: cytoplasm level 4: plasma membrane level 5: cytoplasmic stress granule
External source	Open in SGD