S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Srl3p
Description	Repressor of transcription at Start; binds to SBF (Swi4p-Swi6p) at SCB promoter elements in G1 to repress transcription; inhibitor of Start that retains Cdc28-Cln3 at the ER; acts with Ydj1p to promote release of the complex in a growth-mediated positive feedback loop to trigger Start; Srl3p is unstable and degraded by SCF-Grr1 after Cdc28p-dependent phosphorylation; contains a GTB (G1/S transcription factor binding) motif; binds SBF-regulated promoters in HU-treated cells; Cdc28p substrate
GO Terms: Biological Process	level 4: nucleobase-containing compound metabolic process level 6: negative regulation of transcription involved in G1/S transition of mitotic cell cycle level 7: DNA-templated transcription elongation
GO Terms: Molecular Function	level 3: transcription coregulator activity level 8: RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO Terms: Cellular Component	level 3: cytoplasm level 5: SBF transcription complex
External source	Open in SGD