S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Hsp104p
Description	Disaggregase; heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responds to stresses including heat, ethanol, and sodium arsenite; involved in [PSI+] propagation; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress; potentiated Hsp104p variants decrease TDP-43 proteotoxicity by eliminating its cytoplasmic aggregation
GO Terms: Biological Process	level 3: protein unfolding level 4: protein folding in endoplasmic reticulum level 4: protein refolding level 5: trehalose metabolism in response to heat stress level 5: cellular response to heat level 5: chaperone cofactor-dependent protein refolding level 6: cellular heat acclimation level 7: stress granule disassembly
GO Terms: Molecular Function	level 3: ATP hydrolysis activity level 4: chaperone binding level 4: nucleotide binding level 4: unfolded protein binding level 5: ADP binding level 6: ATP binding
GO Terms: Cellular Component	level 3: cytosol level 3: nuclear periphery level 3: cytoplasm level 4: TRC complex level 5: nucleus
External source	Open in SGD