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Gene Ontology Information

Protein Name Sic1p
Description Cyclin-dependent kinase inhibitor (CKI); inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylated by Clb5/6-Cdk1 and Cln1/2-Cdk1 kinase which regulate timing of Sic1p degradation; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1
GO Terms:
Biological Process
level 5: G1/S transition of mitotic cell cycle external link
level 7: negative regulation of cyclin-dependent protein serine/threonine kinase activity external link
level 7: regulation of cyclin-dependent protein serine/threonine kinase activity external link
level 9: negative regulation of macroautophagy external link
GO Terms:
Molecular Function
level 7: cyclin-dependent protein serine/threonine kinase inhibitor activity external link
GO Terms:
Cellular Component
level 3: cytoplasm external link
level 5: nucleus external link
External source Open in SGD external link
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